Urinary tract infections, upper & lower respiratory tract infections, acute otitis media, gonococcal urethritis & enteric fever.
3rd Generation Cephalosporin; Antibacterial
Cefixime is a third generation semisynthetic cephalosporin antibiotic for oral administration. It is bactericidal against a broad spectrum of gram positive and gram negative bacteria at easily achievable plasma concentrations. It kills bacteria by interfering in the synthesis of bacterial cell wall. It is highly stable in the presence of Beta-lactamase enzyme. As a result, many organisms resistant to penicillins and some cephalsporins due to the presence of beta-lactamases, may be susceptible to Cefixime. Absorption of it is about 40% to 50% whether administered with or without food.
200-400 mg as a single dose or in 2 divided doses daily for 7-14 days, Child dose : 8 mg/kg daily as a single dose or in two divided doses for 7-14 days.
In common with other cephalosporins, increases in prothrombin times have been noted in a few patients. Care should therefore be taken in patients receiving anticoagulant therapy.
Known hypersensitivity to Cephalosporin group of drugs.
Diarrhoea, nausea, abdominal pain, dyspepsia, vomiting, flatulence, headache & dizziness.
Pregnancy Category B. Caution should be exercised when Cefixime is administered to a nursing mother.
Gastric Lavage may be indicated; otherwise, no specific antidote exists. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Adverse reactions in small numbers of healthy adult volunteers receiving single doses up to 2 g of Cefixime did not differ from the profile seen in patients treated at the recommended doses.
Keep below 30ºC temperature, protected from light & moisture. Keep out of the reach of children.
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